Patent Number: 8,575,400

Title: Therapeutic compounds

Abstract: A (-)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful in the treatment or prevention of nausea and vomiting or for promoting an antiemetic effect. ##STR00001##

Inventors: Jenkins; Thomas E. (San Carlos, CA)

Assignee: Signature Therapeutics, Inc.

International Classification: C07C 29/04 (20060101); C07C 39/06 (20060101); A61K 31/05 (20060101)

Expiration Date: 1/05/12017