Patent Number: 8,577,619

Title: Models for combinatorial perturbations of living biological systems

Abstract: Techniques for modeling living biological systems include receiving constant values for multiple interaction factors w.sub.ij. A set of initial state values is received for state variables that indicate relevant properties of a living biological system. Also received is a set of trial values for perturbation variables that indicate factors that might affect one or more of the relevant properties of the biological system. A temporal change in a value for a particular state variable is determined based on a non-linear transformation of a sum of the trial value for the perturbation that affects the particular state added to a sum of all non-zero values for a product of w.sub.ij and a state variable over all state variables. In some embodiments, measurement-based values are received for a measurable subset of the state variables. Values for the constant interaction factors w.sub.ij are determined based on the measurement-based values.

Inventors: Sander; Chris (Cambridge, MA), Nelander; Sven (Gothenburg, SE), Wang; Wei Qing (Jersey City, NJ), Gennemark; Peter (Kungsbacka, SE), Nilsson; Bjorn (Lund, SE)

Assignee: Sloan Kettering Institute for Cancer Research

International Classification: G06F 19/12 (20110101); G06F 19/00 (20110101)

Expiration Date: 1/05/12017