Patent Number: 8,577,624

Title: Crystal structure of a plasma membrane proton pump

Abstract: The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of such modulators. Based on the provided three dimensional structure of the ATPase, various method, such as computer implemented methods may be used for identification of modulators, such putative modulators may be further analysed using in vitro and in vivo experiments to confirm there functionality. Several modulator interaction regions are described as target of regulation by ATPase modulators.

Inventors: Palmgren; Michael G. (Gentorfte, DK), Buch-Pedersen; Morten (Copenhagen, DK), Pedersen; Bjorn Panella (Aarhus, DK), Nissen; Poul (Risskov, DK)

Assignee: Aarhus Universitet

International Classification: G01N 31/00 (20060101); C12Q 1/34 (20060101)

Expiration Date: 1/05/12017