Patent Number: 8,580,562

Title: Inhibitory RNA for modulating the molecular function of ZFAT gene

Abstract: The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence. The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.

Inventors: Shirasawa; Senji (Fukuoka, JP), Fujimoto; Takahiro (Fukuoka, JP), Tsunoda; Toshiyuki (Fukuoka, JP), Doi; Keiko (Fukuoka, JP), Koyanagi; Midori (Fukuoka, JP)

Assignee: Fukuoka University

International Classification: C12N 15/85 (20060101); C12N 15/63 (20060101); C07H 21/02 (20060101); C07H 21/04 (20060101)

Expiration Date: 2022-11-12 0:00:00