Patent Number: 8,580,767

Title: Oxazolidinone containing dimer compounds, compositions and methods to make and use

Abstract: Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: ##STR00001## wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR.sub.1 or NR.sub.1R.sub.2; wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.

Inventors: Hester, II; D. Keith (Delmar, NY), Duguid; Robert J. (Glenmont, NY), Finn; John (Encinitas, CA)

Assignee: Trius Therapeutics, Inc.

International Classification: A01N 57/00 (20060101); C07F 9/28 (20060101); A61K 31/675 (20060101); C07F 9/06 (20060101)

Expiration Date: 2022-11-12 0:00:00