Patent Number: 8,580,975

Title: Synthesis of macrocyclic cancer chemotherapy agents and methods of use

Abstract: Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A.

Inventors: Ghosh; Arun K (West Lafeyette, IN), Xu; Xiaoming (Dallas, TX)

Assignee: Purdue Research Foundation

International Classification: C07D 335/04 (20060101)

Expiration Date: 2022-11-12 0:00:00