Patent Number:
8,580,975
Title:
Synthesis of macrocyclic cancer chemotherapy agents and methods of use
Abstract:
Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A.
Inventors:
Ghosh; Arun K (West Lafeyette, IN), Xu; Xiaoming (Dallas, TX)
Assignee:
Purdue Research Foundation
International Classification:
C07D 335/04 (20060101)
Expiration Date:
2022-11-12 0:00:00