Patent Number:
8,586,039
Title:
Degraded TPO agonist antibody
Abstract:
The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.
Inventors:
Tsuchiya; Masayuki (Shizuoka-ken, JP), Ohtomo; Toshihiko (Shizuoka-ken, JP), Yabuta; Naohiro (Ibaraki, JP), Tsunoda; Hiroyuki (Ibaraki, JP), Orita; Tetsuro (Ibaraki, JP)
Assignee:
Chugai Seiyaku Kabushiki Kaisha
International Classification:
A61K 38/00 (20060101)
Expiration Date:
1/19/12018