Patent Number: 8,586,039

Title: Degraded TPO agonist antibody

Abstract: The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.

Inventors: Tsuchiya; Masayuki (Shizuoka-ken, JP), Ohtomo; Toshihiko (Shizuoka-ken, JP), Yabuta; Naohiro (Ibaraki, JP), Tsunoda; Hiroyuki (Ibaraki, JP), Orita; Tetsuro (Ibaraki, JP)

Assignee: Chugai Seiyaku Kabushiki Kaisha

International Classification: A61K 38/00 (20060101)

Expiration Date: 1/19/12018