Patent Number: 8,586,103

Title: Non-polymeric compositions for controlled drug delivery

Abstract: The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.

Inventors: Li; Yuhua (Newark, DE), Guarino; Andrew (Newark, DE), Chien; Benjamin (Woodside, CA)

Assignee: Foresee Pharmaceuticals, LLC

International Classification: A01N 65/00 (20090101)

Expiration Date: 1/19/12018