Patent Number: 8,658,177

Title: Promiscuous HER-2/Neu CD4 T cell epitopes

Abstract: The present invention relates to the discovery of novel T cell epitopes of the human HER-2/Neu protein that is promiscuous for at least 25 different HLA-DR alleles. The invention also relates to compositions that contain one of the novel epitopes or a fusion peptide of such a epitope and a heterologous polypeptide. Further disclosed herein is the use of the epitopes or their fusion peptides, and compositions containing the epitopes or their fusion peptides.

Inventors: Wollan; Jami B. (Mountlake Terrace, WA), Jones; Lori A. (Seattle, WA)

Assignee: Dendreon Corporation

International Classification: A61K 39/00 (20060101)

Expiration Date: 2022-02-25 0:00:00