Patent Number: 8,658,368

Title: Microfabricated crossflow devices and methods

Abstract: A microfluidic device is provided for analyzing or sorting biological materials, such as polynucleotides, polypeptides, proteins, enzymes, viruses and cells. The invention can be used for high throughput or combinatorial screening. The device comprises a main channel and an inlet channel that communicate at a droplet extrusion region so that droplets of solution are deposited into an immiscible solvent in the main channel. Droplets can thereafter be sorted according to biological material detected in each droplet.

Inventors: Quake; Stephen R. (Stanford, CA), Thorsen; Todd (Pasadena, CA)

Assignee: California Institute of Technology

International Classification: C12Q 1/68 (20060101); B01F 3/08 (20060101); G01N 35/08 (20060101); C12M 1/34 (20060101)

Expiration Date: 2022-02-25 0:00:00