Patent Number: 8,715,670

Title: Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

Inventors: Lee; Jung Tae (Daejeon, KR), Moon; Kyung Duk (Daejeon, KR), Yoon; Ji Yong (Daejeon, KR), Sung; Byung Je (Daejeon, KR), Lee; Dong Heon (Daejeon, KR), Lee; Il Sun (Daejeon, KR), Lee; Dong Eun (Busan, KR), Ryu; Su Yeon (Daejeon, KR), Park; Young Woo (Daejeon, KR), Choi; So Young (Daejeon, KR), Park; Ji Hyun (Gyeongsangnam-do, KR), Jang; Myeoung Hee (Daejeon, KR)

Assignee: Hanwha Chemical Corporation

International Classification: A61K 39/395 (20060101); C07K 16/28 (20060101); G01N 33/53 (20060101)

Expiration Date: 5/06/12018