Patent Number: 8,715,697

Title: Genes associated with Leishmania parasite virulence

Abstract: The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His-Cys) of the potential active site of the protein disulphide isomerase (PDI). The LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. Said protein forms a novel therapeutic target for developing anti-leishmaniasis medicaments and a novel element that can be used in the composition of immunogenic, and possibly vaccinating, preparations which are intended to protect a human or animal host against Leishmania.

Inventors: Ben Achour; Yosser (La Marsa, TN), Chenik; Mehdi (La Marsa, TN), Louzir; Hechmi (La Marsa, TN), Dellagi; Koussay (Tunis, TN)

Assignee: Institut Pasteur de Tunis

International Classification: A61K 39/00 (20060101); A61K 39/002 (20060101); A61K 45/00 (20060101); A61K 47/00 (20060101)

Expiration Date: 5/06/12018