Patent Number: 8,715,719

Title: Stable chitosan hemostatic implant and methods of manufacture

Abstract: A method of preparing a stable chitosan hemostatic implant including preparing a lyophilizable solution of chitosan polymers and freezing the solution to obtain a frozen chitosan composition. The method further includes placing the frozen chitosan composition under vacuum so as to substantially dry the chitosan composition and curing the dried chitosan composition by first exposing it to a relative humidity and then curing the dried chitosan composition under heat so as to crosslink the chitosan polymers.

Inventors: Roorda; Wouter E. (Palo Alto, CA), McCoy; Jill A. (Evanston, IL), Seto; Richard (San Francisco, CA), Michal; Eugene T. (San Francisco, CA)

Assignee: Abbott Vascular, Inc.

International Classification: A61K 9/00 (20060101); A61K 9/14 (20060101); A61P 17/02 (20060101); A61K 31/722 (20060101)

Expiration Date: 5/06/12018