Patent Number: 8,715,999

Title: Flaviviridae mutants comprising a deletion in the capsid protein for use as vaccines

Abstract: The present invention relates to a mutant virus of the family flaviviridae, comprising a deletion in the capsid protein of at least 20 successive amino acids, without any further deletion, substitution or insertion mutation except of the amino acids next to the deletion, which may be substituted.

Inventors: Heinz; Franz X. (Vienna, AT), Mandl; Christian (Vienna, AT), Schlick; Petra (Vienna, AT), Meinke; Andreas (Pressbaum, AT)

Assignee: Valneva Austria GmbH

International Classification: C12N 7/04 (20060101); C12N 15/86 (20060101)

Expiration Date: 5/06/12018