Patent Number: 8,716,020

Title: Reprogrammation of eukaryotic cells with engineered microvesicles

Abstract: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.

Inventors: Mangeot; Philippe (Lyon Cedex, FR), Lotteau; Vincent (Lyon Cedex, FR), Peschanski; Marc (Evry Cedex, FR), Girard; Mathilde (Evry Cedex, FR)

Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale)

International Classification: C12N 5/07 (20100101); C12N 5/073 (20100101)

Expiration Date: 5/06/12018