Patent Number: 8,716,220

Title: Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta

Abstract: The present disclosure provides compositions containing a leptin product and methods of clinical therapy and diagnostic methods for progressive cognitive disorders. According to one aspect, the described invention provides a method for treating a progressive cognitive disorder. According to another aspect, the described invention provides a method for improving resilience of cognitive function in a subject in need thereof. According to another aspect, the described invention provides a method for identifying an effective therapeutic agent for treating a progressive cognitive dysfunction disease or disorder that results from at least one of accumulation of A.beta., hyperphosphorylation of tau, or accumulation of neurofibrillary tangles.

Inventors: Tezapsidis; Nikolaos (West Orange, NJ), Greco; Steven J. (Carlstadt, NJ), Smith; Mark (Cleveland, OH)

Assignee:

International Classification: A61K 38/22 (20060101)

Expiration Date: 5/06/12018