Patent Number: 8,716,230

Title: Methods for treatment or prevention of diseases associated with functional disorder of regulatory T cells

Abstract: The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.

Inventors: Suzumura; Akio (Aichi, JP), Wang; Jinyan (Aichi, JP), Matsui; Takashi (Kanagawa, JP), Sakuma; Sadatoshi (Kanagawa, JP), Miyakawa; Shin (Tokyo, JP), Fujiwara; Masatoshi (Tokyo, JP), Nakamura; Yoshikazu (Tokyo, JP)

Assignee: Ribomic Inc.

International Classification: A61K 51/08 (20060101); A61K 31/7088 (20060101); C07K 2/00 (20060101); C07H 21/04 (20060101)

Expiration Date: 5/06/12018