Patent Number: 8,716,237

Title: Methods for the treatment or prevention of hemorrhagic conditions

Abstract: The present invention relates to a method for treatment or prevention of a hemorrhagic condition in a patient by administering plasminogen activator inhibitor-1 ("PAI-1") and/or an inhibitor of deubiquitinating enzyme CYLD ("CYLD") to a patient. Pharmaceutical compositions that include one or both of PAI-1 and an inhibitor of CYLD are also disclosed.

Inventors: Li; Jian-Dong (Pittsford, NY), Lim; Jae Hyang (Rochester, NY)

Assignee: University of Rochester

International Classification: A61K 38/36 (20060101); A61K 38/55 (20060101); A61K 38/16 (20060101)

Expiration Date: 5/06/12018