Patent Number: 8,716,276

Title: Thiophenyl and pyrrolyl azepines as serotonin 5-HT.sub.2C receptor ligands and uses thereof

Abstract: The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT.sub.2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT.sub.2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).

Inventors: Tumey; L. Nathan (Pawcatuck, CT), Bom; David C. (Cincinnati, OH), Bennani; Youssef L. (Boston, MA), Robarge; Michael J. (Chagrin Falls, OH)

Assignee: Athersys, Inc.

International Classification: A61P 25/00 (20060101); C07D 487/02 (20060101); C07D 223/16 (20060101); A61K 31/55 (20060101)

Expiration Date: 5/06/12018