Patent Number: 8,716,279

Title: Pharmaceutical compositions of clonazepam and method of use thereof

Abstract: The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is soluble, the first solvent capable of penetrating nasal mucosal tissue, and a second solvent in which the benzodiazepine in less soluble. The compositions of the present invention may be used to treat a variety of disorders including, but not limited to, panic attacks, muscle spasms, anxiety, and seizures. In one aspect, the present invention relates to a fast-acting, clonazepam composition for transnasal administration that can be used for the treatment of seizure clusters.

Inventors: Jamieson; Gene (Boulder Creek, CA), Des Jardin; Michael (Sunnyvale, CA), Allphin; Clark (Los Altos, CA), Olafsdottir; Sigridur (Reykjavik, IS)

Assignee: Jazz Pharmaceuticals, Inc.

International Classification: A01N 43/62 (20060101)

Expiration Date: 5/06/12018