Patent Number: 8,716,300

Title: Frequency modulated drug delivery (FMDD)

Abstract: Embodiments of the present disclosure include a coordination complex, comprising a first biologically active moiety, a second biologically active moiety, and a metal, wherein the first biologically active moiety and second biologically active moiety are bound to the metal by covalent coordination bonds, and wherein the first biologically active moiety and second biologically active moiety are different. These complexes may enhance the pharmacodynamic properties of biologically active moieties.

Inventors: Piccariello; Thomas (Blacksburg, VA), Palmer; Scott B. (Wilmette, IL), Price; John D. (Blacksburg, VA), Oberlender; Robert (Blacksburg, VA), Spencer; Mary C. (Blacksburg, VA), Mulhare; Michaela E. (Christiansburg, VA)

Assignee: Synthonics, Inc.

International Classification: A61K 31/522 (20060101); C07D 233/00 (20060101); C07D 473/00 (20060101)

Expiration Date: 5/06/12018