Patent Number: 8,716,304

Title: Preparation method of MLN4924 as an E1 activating inhibitor

Abstract: The present invention relates to a method for preparation of MLN4924 as an E1 activating inhibitor, and more specifically, to a method for efficient and stereoselective preparation of MLN4924 by means of key steps involving stereoselective reduction of cyclopentenone with isopropylidene, regioselective cleavage of isopropylidene moiety, and synthesis of cyclic sulfate.

Inventors: Jeong; Lak Shin (Seoul, KR), Lee; Hyuk Woo (Gyeonggi-do, KR)

Assignee: EWHA University--Industry Collaboration Foundation

International Classification: A01N 43/90 (20060101); A61K 31/519 (20060101); C07D 497/00 (20060101)

Expiration Date: 5/06/12018