Patent Number: 8,716,312

Title: Inhibitors of diacylglycerol acyltransferase

Abstract: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below: ##STR00001##

Inventors: Ting; Pauline C. (New Providence, NJ), Aslanian; Robert (Rockaway, NJ), Caplen; Mary Ann (Sayreville, NJ), Cao; Jianhua (Edison, NJ), Chan; Tin-Yau (Edison, NJ), Kim; David (North Bergen, NJ), Kim; Hyunjin (Livingston, NJ), Kim; Jae-Hun (Scotch Plains, NJ), Kuang; Rongze (Green Brook, NJ), Lee; Joe F. (Brooklyn, NY), Schwerdt; John (Lake Hiawatha, NJ), Wu; Heping (Edison, NJ), Zorn; Nicolas (Short Hills, NJ)

Assignee: Merck Sharp & Dohme Corporation

International Classification: A61P 3/00 (20060101); A61K 31/445 (20060101); C07D 413/12 (20060101); C07D 413/14 (20060101); C07D 417/12 (20060101); C07D 417/14 (20060101); A61P 9/00 (20060101)

Expiration Date: 5/06/12018