Patent Number: 8,716,528

Title: Aryloxy amine compounds and their use as sodium channel modulators

Abstract: The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.

Inventors: Jarrott; Bevyn (North Melbourne, AU)

Assignee: Howard Florey Institute

International Classification: C07C 213/00 (20060101); C07C 217/00 (20060101); C07C 215/00 (20060101)

Expiration Date: 5/06/12018