Patent Number: 8,721,892

Title: Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same

Abstract: Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.

Inventors: Shih; Chi-Yuan (Pasadena, CA), Tai; Yu-Chong (Pasadena, CA), Xie; Jun (Clifton Park, NY), Young; Darron K. (South Pasadena, CA), Chen; Po-Jui (Cupertino, CA)

Assignee: California Institute of Technology

International Classification: B01D 15/08 (20060101); G01N 30/02 (20060101); C02F 1/28 (20060101)

Expiration Date: 5/13/12018