Patent Number: 8,722,043

Title: Induction of p53 expression by neutralization of neuropilin-2 for the treatment of cancers

Abstract: The present invention relates to the use of anti-human neuropilin-2 antibodies, or of ligands of human neuropilin-2 derived from these antibodies, for obtaining a medicament intended to increase p53 expression and to induce tumor cell apoptosis in the context of an anticancer treatment.

Inventors: Borg; Christophe (Pouillet les Vignes, FR), Wijdenes; John (Larnod, FR), Grandclement; Camille (Besancon, FR)

Assignee: Diaclone

International Classification: A61K 39/395 (20060101); C07K 16/00 (20060101)

Expiration Date: 5/13/12018