Patent Number: 8,722,052

Title: Vaccinia virus protein A46 peptide and use thereof

Abstract: A peptide for inhibiting Toll-like receptor 4 (TLR4) signalling comprising the amino acid sequence of SEQ ID NO. 4, SEQ ID NO 55, SEQ ID NO 68, SEQ ID NO. 69, SEQ ID NO 70, SEQ ID NO 71, SEQ ID NO 72, SEQ ID NO 79, SEQ ID NO 82, SEQ ID NO 85, SEQ ID NO 88, SEQ ID NO 91, SEQ ID NO 94, SEQ ID NO 97, SEQ ID NO 100, SEQ ID NO 103, SEQ ID NO 106, SEQ ID NO 109, SEQ ID NO 112, or SEQ ID NO 115. The peptide may comprise a delivery sequence such as a cationic peptide.

Inventors: Bowie; Andrew Graham (Dublin, IE), Harrington; Barry Noel (Dublin, IE), Lysakova; Tatyana Sergeevna (Kildare, IE), Keogh; Brian (Dublin, IE)

Assignee: The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, near Dublin

International Classification: A61K 39/12 (20060101); A61K 39/08 (20060101); A61K 39/275 (20060101); C12N 7/04 (20060101)

Expiration Date: 5/13/12018