Patent Number: 8,722,078

Title: Polymeric device for controlled release of active agents

Abstract: Polymeric devices for controlled release of an active agent of interest are provided. The active agent is provided within a biodegradable polymer system to supply a polymeric device for controlled release of the active agent. The polymer system is a copolymer or a polymer blend comprising a hydrophobic component and a hydrophilic component, and the polymer system does not form a hydrogel when contacted with, or immersed in an aqueous system, for example when the device is implanted in a subject. When the device is administered to a subject, for example, when it is implanted, the device releases the active agent in a controlled fashion without a lag period, or with a minimal lag period. Methods for producing the polymeric devices are also provided, as are methods of using the polymeric devices to provide for controlled release of an active agent in a subject.

Inventors: Gibson; John W. (Springville, AL), Tipton; Arthur J. (Birmingham, AL)

Assignee: Durect Corporation

International Classification: A61F 2/00 (20060101); C07K 14/00 (20060101)

Expiration Date: 5/13/12018