Patent Number: 8,722,399

Title: Agents and method for treating inflammation-related conditions and diseases

Abstract: Gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages. Gene-modified, inflammation-specific macrophages that comprise a 1-alpha-hydroxylase gene. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, inflammation-specific monocytes that comprise a 1-alpha-hydroxylase gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme when the monocytes transdifferentiate into gene-modified, inflammation-specific macrophages.

Inventors: Baylink; David J. (Redlands, CA), Lau; Kin-Hing William (Redlands, CA), Qin; Xuezhong (Loma Linda, CA)

Assignee: Loma Linda University

International Classification: C12N 5/00 (20060101); C12N 5/02 (20060101)

Expiration Date: 5/13/12018