Patent Number: 8,722,663

Title: Di-substituted pyridine derivatives as anticancers

Abstract: The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R.sup.1 and R.sup.2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is --NH-G.sub.2-, --N(lower alkyl)-G.sub.2-, --NH--CH.sub.2-G.sub.2-, --N(lower alkyl)-CH.sub.2-G.sub.2- or --CH.sub.2-G.sub.2-, [wherein G.sub.2 binds to R.sup.2, G.sub.2-R.sup.2 is bond-R.sup.2, phenylene-G.sub.3-R.sup.2, phenylene-G.sub.4-O--R.sup.2, phenylene-G.sub.5-NH--R.sup.2, phenylene-G.sub.6-N(lower alkyl)-R.sup.2 or quinolinediyl-O--R.sup.2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G.sub.3-R.sup.2 is --O-lower alkylene-R.sup.2 or the like; G.sub.4-O-- is lower alkylene-O-- or the like; G.sub.5 is lower alkylene; G.sub.6 is lower alkylene]. ##STR00001##

Inventors: Takasu; Hideki (Osaka, JP), Fujita; Shigekazu (Osaka, JP), Ohtsuka; Shinya (Osaka, JP), Hirose; Toshiyuki (Osaka, JP), Sato; Yosuke (Osaka, JP), Yamada; Satoshi (Osaka, JP), Miyajima; Keisuke (Osaka, JP), Sakai; Koji (Osaka, JP), Kojima; Yutaka (Osaka, JP), Sekiguchi; Kazuo (Osaka, JP), Yanagihara; Yasuo (Osaka, JP), Suzuki; Takashi (Osaka, JP), Tanaka; Hideo (Osaka, JP), Sugiyama; Kazuhisa (Osaka, JP), Okuno; Mitsuhiro (Osaka, JP), Sumida; Takumi (Osaka, JP)

Assignee: Otsuka Pharmaceutical Co., Ltd.

International Classification: A61K 31/44 (20060101); C07D 213/69 (20060101); C07D 401/12 (20060101); C07D 405/12 (20060101); C07D 413/12 (20060101); A61K 31/551 (20060101); A61K 31/553 (20060101); A61K 31/496 (20060101); A61K 31/443 (20060101); A61K 31/4725 (20060101); A61K 31/4545 (20060101); A61K 31/4439 (20060101)

Expiration Date: 5/13/12018