Patent Number: 8,791,068

Title: Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

Abstract: A novel group of gastrokines called Gastric Antrum Mucosal Protein is characterized. A member of the group is designated AMP-18. AMP-18 genomic DNA, cDNA and the AMP-18 protein are sequenced for human, mouse and pig. The AMP-18 protein and active peptides derived from it are cellular growth factors. Surprisingly, peptides capable of inhibiting the effects of the complete protein, are also derived from the AMP-18 protein. Cytoprotection and control of mammalian gastro-intestinal tissue growth and repair (restitution) is facilitated by the use of the proteins, making the proteins candidates for therapies in inflammatory bowel disease and gastric ulcers.

Inventors: Martin; Terence E. (Chicago, IL), Toback; F. Gary (Chicago, IL), Walsh-Reitz; Margaret (River Forest, IL)

Assignee: The University of Chicago

International Classification: A61K 38/16 (20060101)

Expiration Date: 7/29/12018