Patent Number: 8,791,069

Title: Pharmaceutical composition of nanoparticles

Abstract: The invention discloses use of a pharmaceutical composition for slow-release delivery of a bioactive agent, comprising mixing the bioactive agent with a partially hydrophobic chitosan solution at a low pH and delivering the hydrogel at a physiological pH to transform the hydrogel to a solid complex for releasing the bioactive agent. The partially hydrophobic chitosan is characterized by presence of alternating charges of protonated amine groups and hydrophobic side groups.

Inventors: Sung; Hsing-Wen (Hsinchu, TW), Tu; Hosheng (Newport Beach, CA)

Assignee: GP Medical, Inc.

International Classification: A61K 38/00 (20060101)

Expiration Date: 7/29/12018