Patent Number: 8,791,079

Title: Methods for treating heart failure by inhibiting the mitochondrial sodium-calcium exchanger (mNCE)

Abstract: Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions for preventing or reducing the occurrence of conditions associated with heart failure, including, but not limited to, sudden cardiac death and contractile decompensation, by inhibiting the mNCE also are provided.

Inventors: O'Rourke; Brian (Sparks, MD), Liu; Ting (Parkville, MD)

Assignee: The Johns Hopkins University

International Classification: A61K 31/7048 (20060101); A61K 31/554 (20060101); A61P 9/00 (20060101)

Expiration Date: 7/29/12018