Patent Number: 8,791,083

Title: Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry

Abstract: The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3'-endo conformational geometry (3'-endo regions) or DNA like having southern or C2'-endo/O4'-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.

Inventors: Monia; Brett P. (Encinitas, CA), Butler; Madeline M. (Rancho Santa Fe, CA), McKay; Robert (Oceanside, CA), Baker; Brenda F. (Carlsbad, CA)

Assignee: Isis Pharmaceuticals, Inc.

International Classification: C12N 15/11 (20060101)

Expiration Date: 7/29/12018