Patent Number: 8,791,086

Title: Polyion complex comprising PHD2 expression inhibiting substance

Abstract: The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.

Inventors: Kataoka; Kazunori (Tokyo, JP), Wu; Shourong (Tokyo, JP), Nishiyama; Nobuhiro (Tokyo, JP), Itaka; Keiji (Tokyo, JP), Koyama; Hiroyuki (Tokyo, JP), Hashimoto; Takuya (Tokyo, JP), Tei; Yuichi (Tokyo, JP)

Assignee: The University of Tokyo

International Classification: A01N 43/04 (20060101); C07H 21/04 (20060101); C12N 15/87 (20060101)

Expiration Date: 7/29/12018