Patent Number: 8,791,090

Title: Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R.sup.1, R.sup.2, R.sup.2', R.sup.3 and R.sup.3' independently represent a hydrogen atom, a C.sub.1-6 alkyl group, or the like; R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 independently represent a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, or the like; A represents N--R.sup.11, a sulfur atom, or an oxygen atom; R.sup.11 represents a hydrogen atom, a C.sub.1-6 alkyl group, or the like; B represents a C.sub.6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Inventors: Ashikawa; Masanori (Tokyo, JP), Tagashira; Junya (Tokyo, JP), Koketsu; Akiyasu (Tokyo, JP), Morimoto; Toshiharu (Tokyo, JP), Kitamura; Takahiro (Shizuoka, JP), Takemura; Syunji (Tokyo, JP), Watanabe; Gen (Tokyo, JP), Nishiyama; Tatsuaki (Tokyo, JP), Goda; Satoshi (Tokyo, JP), Yamabi; Masaki (Tokyo, JP), Doi; Takeshi (Tokyo, JP), Ishiwata; Hiroyuki (Tokyo, JP)

Assignee: Kowa Company, Ltd.

International Classification: A01N 57/00 (20060101); A61K 31/385 (20060101)

Expiration Date: 7/29/12018