Patent Number: 8,791,095

Title: Steroidal CYP17 inhibitors/antiandrogens

Abstract: Steroidal C-17 nitrogen-containing heterocycles of Formula I: ##STR00001## wherein: the ABCD ring structure is the nucleus of a steroid, or an analog thereof, X is a group capable of coordinating a heme group of CYP17, and Y is an hydroxyl functionality, a suitable ester, or a prodrug group, for the treatment of urogenital and/or androgen-related cancers, such as castration-resistant prostate cancer. The invention provides methods of synthesizing new chemical entities and methods of using the same in treating urogenital and/or androgen-related cancers.

Inventors: Casebier; David (Carlisle, MA)

Assignee: Tokai Pharmaceuticals, Inc.

International Classification: A61K 31/58 (20060101); C07J 43/00 (20060101)

Expiration Date: 7/29/12018