Patent Number: 8,791,098

Title: Bioactive pre-tubulysins and use thereof

Abstract: The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.

Inventors: Chai; Yi (Ithaca, NY), Ullrich; Angelika (Blieskastel, DE), Kazmaier; Uli (Homburg, DE), Muller; Rolf (Blieskastel, DE)

Assignee: Universitaet des Saarlandes

International Classification: A01N 43/40 (20060101); C07D 405/00 (20060101); A61K 31/33 (20060101); A01N 43/00 (20060101); A61K 31/445 (20060101)

Expiration Date: 7/29/12018