Patent Number: 8,791,102

Title: Acetanilide sphingosine-1-phosphate receptor antagonists

Abstract: This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particular, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

Inventors: Ibrahim; Mohamed Abdulkader (Mountain View, CA), Jeong; Joon Won (Belmont, CA), Johnson; Henry William Beecroft (San Bruno, CA), Kearney; Patrick (San Francisco, CA), Leahy; James W. (San Leandro, CA), Lewis; Gary L. (San Francisco, CA), Noguchi; Robin Tammie (San Bruno, CA), Nuss; John M. (Danville, CA)

Assignee: Exelixis, Inc.

International Classification: A61K 31/4196 (20060101); A61K 31/4192 (20060101); A61K 31/167 (20060101); A61K 31/341 (20060101); A61K 31/4015 (20060101); A61K 31/455 (20060101); A61K 31/506 (20060101); A61K 31/541 (20060101); A61K 31/55 (20060101); C07D 403/06 (20060101); C07D 403/04 (20060101); C07D 307/54 (20060101); C07D 223/04 (20060101); C07D 213/56 (20060101); C07D 207/452 (20060101); A61P 35/02 (20060101); A61P 35/00 (20060101); C07D 417/06 (20060101); A61K 31/417 (20060101)

Expiration Date: 7/29/12018