Patent Number: 8,791,109

Title: Compositions containing micronized tanaproget prepared by wet granulation

Abstract: Compositions, preferably pharmaceutical compositions, containing micronized tanaproget, or pharmaceutically acceptable salt thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, butylated hydroxyanisole, povidone, and magnesium stearate, are provided. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic to disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.

Inventors: Nagi; Arwinder S. (Moorpark, CA), Chatlapalli; Ramarao S. (Hopewell Junction, NY), Hasan; Shamim (East Elmhurst, NY), Carson; Rolland W. (Middletown, NY), Ghorab; Mohamed (West Lafayette, IN)

Assignee: Wyeth LLC

International Classification: A61K 31/535 (20060101)

Expiration Date: 7/29/12018