Patent Number: 8,791,118

Title: Pyridopyrazines as highly selective ras-Raf-Mek-Erk signal transduction pathway inhibitors

Abstract: The invention provides new pyridopyrazine compounds according to formula (I) ##STR00001## which are highly selective as Ras-Raf-Mek-Erk signal transduction pathway inhibitors and in particular are highly selective Erk inhibitors.

Inventors: Gerlach; Matthias (Brachttal, DE), Seipelt; Irene (Offenbach, DE), Blumenstein; Lars (Frankfurt am Main, DE), Mueller; Gilbert (Frankfurt am Main, DE), Guenther; Eckhard (Maintal, DE), Schuster; Tilmann (Grossostheim, DE), Teifel; Michael (Weiterstadt, DE)

Assignee: Aeterna Zentaris GmbH

International Classification: A61K 31/4985 (20060101); C07D 487/04 (20060101)

Expiration Date: 7/29/12018