Patent Number: 8,791,132

Title: Compounds and methods for treatment of hypertension

Abstract: Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor .alpha..sub.2B antagonists. The compounds may also bind to and antagonize adrenergic receptor .alpha..sub.1B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.

Inventors: Protter; Andrew Asher (Palo Alto, CA), Chakravarty; Sarvajit (Mountain View, CA), Jain; Rajendra Parasmal (Pune, IN), Green; Michael John (Half Moon Bay, CA)

Assignee: Medivation Technologies, Inc.

International Classification: A61K 31/04 (20060101)

Expiration Date: 7/29/12018