Patent Number: 8,791,263

Title: Cortistatin A analog and use thereof

Abstract: A compound represented by the general formula (M): ##STR00001## (wherein R.sup.1 represents a substituted or unsubstituted aromatic heterocyclic group, R.sup.2 represents a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms, OR.sup.3, N(R.sup.3).sub.2, C(.dbd.O)OR.sup.3 or C(.dbd.O)N(R.sup.3).sub.2, R.sup.3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 4 carbon atoms, R.sup.4 represents a hydrogen atom, an oxygen atom or OR.sup.5, and R.sup.5 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 1 to 3 carbon atoms); or a pharmaceutically acceptable salt thereof is a cortistatin A analog which is useful as an active ingredient of medicaments for cancer prevention or treatment in that the analog can be mass-produced by chemical synthesis due to its simple chemical structure and retains the same biological activities as those of cortistatin A.

Inventors: Kobayashi; Motomasa (Osaka, JP), Kotoku; Naoyuki (Osaka, JP), Arai; Masayoshi (Osaka, JP), Tamura; Satoru (Osaka, JP)

Assignee: Osaka University

International Classification: C07D 405/04 (20060101); C07D 217/02 (20060101); A61P 35/00 (20060101); A61P 43/00 (20060101); A61K 31/4725 (20060101); A61K 45/00 (20060101)

Expiration Date: 7/29/12018