Patent Number: 8,791,267

Title: Biaryl PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders

Abstract: The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: ##STR00001## A particular embodiment is ##STR00002##

Inventors: Singh; Jasbir (Naperville, IL), Gurney; Mark E. (Grand Rapids, MI), Burgin; Alex (Kingston, WA), Sandanayaka; Vincent (Northboro, MA), Kiselyov; Alexander (San Diego, CA), Motta; Adalie (Naperville, IL), Schiltz; Gary (Naperville, IL), Hategan; Georgeta (Naperville, IL), Hagen; Timothy (Lisle, IL)

Assignee: Decode Genetics EHF

International Classification: C07D 213/72 (20060101); A61K 31/435 (20060101)

Expiration Date: 7/29/12018