Patent Number: 8,795,653

Title: Methods for repressing B cell autoantibody secretion and for treating autoimmune disorders by administration of hematopoietic stem cells and macrophage-colony stimulating factor

Abstract: The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders using regulatory immune cells or precursors thereto such as hematopoietic stem cells (HSC). The invention also provides methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders by administration of HSC and Macrophage-Colony Stimulating Factor (M-CSF). Further provided are methods of diagnosing in a mammalian subject a defect in regulatory cell mediated repression of autoantibody secretion by B cells.

Inventors: Vilen; Barbara J. (Durham, NC), Kilmon; Michelle (Morrisville, NC), Rutan; Jennifer A. (Carrboro, NC)

Assignee: The University of North Carolina at Chapel Hill

International Classification: A01N 63/00 (20060101); A61K 45/00 (20060101); A61K 47/00 (20060101)

Expiration Date: 8/05/12018