Patent Number: 8,795,659

Title: Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents

Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula I: ##STR00001## (I) wherein A.sup.+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

Inventors: Morgan; Lee R. (New Orleans, LA)

Assignee: Dekk-Tec, Inc.

International Classification: A61K 39/395 (20060101); A61K 38/43 (20060101); A61K 38/46 (20060101); C07F 9/22 (20060101); A61K 31/685 (20060101); A61K 31/70 (20060101); A61K 38/14 (20060101)

Expiration Date: 8/05/12018