Patent Number: 8,795,687

Title: West Nile virus prM-E signal peptide facilitating the efficient assembly, maturation, and release of virus-like particles (VLPs)

Abstract: The present invention provides virus-like particles (VLP) highly secreting or producing signal peptide obtained by altering a signal sequence derived from West Nile virus (WNV), the signal peptide, a WNV VLP secretion expression vector containing a nucleic acid encoding prM protein and E protein, a WNP VLP highly secreting or producing animal cell line harboring the vector, a WNV vaccine containing WNV VLP obtained by the cell line as an active ingredient, and a WNV DNA vaccine containing the VLP secretion expression vector as an active ingredient.

Inventors: Kojima; Asato (Tokyo, JP), Takahashi; Hidehiro (Tokyo, JP), Ishikawa; Toyokazu (Kagawa, JP)

Assignee: Japan as Represented by the Director-General of National Institute of Infections Diseases

International Classification: A61K 39/12 (20060101); A61K 38/00 (20060101)

Expiration Date: 8/05/12018