Patent Number: 8,795,734

Title: Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells

Abstract: Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.

Inventors: Dai; Hongjie (Cupertino, CA), Kam; Nadine Wong Shi (Ann Arbor, MI), Wender; Paul A. (Menlo Park, CA), Liu; Zhuang (Stanford, CA)

Assignee: The Board of Trustees of the Leland Stanford Junior University

International Classification: A61K 9/16 (20060101); A61K 9/50 (20060101); A61K 38/54 (20060101); A61K 39/00 (20060101); B82Y 5/00 (20110101); C12N 15/11 (20060101); A61K 48/00 (20060101)

Expiration Date: 8/05/12018