Patent Number: 8,796,022

Title: Generation of functional basal forebrain cholinergic neurons from stem cells

Abstract: The present invention provides method, compositions, and systems for generating basal forebrain cholinergic neurons (BFCNs) using FGF8, SHH, LXH8, GBX1, or vectors encoding these ligands, as well as using such BFCNs to treat neurological disorders such as Alzheimer's disease.

Inventors: Bissonnette; Christopher (Chicago, IL), Kessler; John (Chicago, IL)

Assignee: Northwestern University

International Classification: C12N 5/0793 (20100101); A61K 35/30 (20060101); C12N 15/85 (20060101); A61P 25/28 (20060101); C12N 5/0735 (20100101); C12N 5/0797 (20100101)

Expiration Date: 8/05/12018