Patent Number: 8,796,229

Title: Feedback prodrug

Abstract: Compounds and methods for use in selectively inhibiting a lytic enzyme based on feedback inhibition are described. The conjugated compound serves as a substrate for a lytic enzyme. Cleavage of the conjugated compound by the lytic enzyme releases an inhibitor of the enzyme.

Inventors: Boons; Geert-Jan (Athens, GA), Guo; Jun (Athens, GA)

Assignee: University of Georgia Research Foundation, Inc.

International Classification: A61K 47/00 (20060101); A61K 47/48 (20060101)

Expiration Date: 8/05/12018